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Conservation between the RNA polymerase I, II, and III transcription initiation machineries.

Authors: Vannini, A  Cramer, P 
Citation: Vannini A and Cramer P, Mol Cell. 2012 Feb 24;45(4):439-46. doi: 10.1016/j.molcel.2012.01.023.
Pubmed: (View Article at PubMed) PMID:22365827
DOI: Full-text: DOI:10.1016/j.molcel.2012.01.023

Recent studies of the three eukaryotic transcription machineries revealed that all initiation complexes share a conserved core. This core consists of the RNA polymerase (I, II, or III), the TATA box-binding protein (TBP), and transcription factors TFIIB, TFIIE, and TFIIF (for Pol II) or proteins structurally and functionally related to parts of these factors (for Pol I and Pol III). The conserved core initiation complex stabilizes the open DNA promoter complex and directs initial RNA synthesis. The periphery of the core initiation complex is decorated by additional polymerase-specific factors that account for functional differences in promoter recognition and opening, and gene class-specific regulation. This review outlines the similarities and differences between these important molecular machines.


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CRRD Object Information
CRRD ID: 9588262
Created: 2014-10-23
Species: All species
Last Modified: 2014-10-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.