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The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression.

Authors: Young, LC  Hendzel, MJ 
Citation: Young LC and Hendzel MJ, Biochem Cell Biol. 2013 Dec;91(6):369-77. doi: 10.1139/bcb-2012-0054. Epub 2012 Dec 5.
Pubmed: (View Article at PubMed) PMID:24219278
DOI: Full-text: DOI:10.1139/bcb-2012-0054

The Jumonji D2 proteins (JMJD2/KDM4) function to demethylate di- and trimethylated (me2/3) histone 3 lysine 9 (H3K9me2/3) and H3K36me3. Knockout mouse models for Kdm4b and Kdm4d have not resulted in gross abnormalities, while mouse models for Kdm4a and Kdm4c have not been reported. However, the KDM4 subfamily of demethylases are overexpressed in several tumor types. Overexpression of KDM4 proteins alters transcription and chromatin remodeling, driving cellular proliferation, anchorage-independent growth, invasion, and migration. Increased proliferation occurs through KDM4-mediated modification of cell cycle timing, as well as through increased numbers of replication forks. Recent evidence also suggests that KDM4C overexpression contributes to the maintenance of a pluripotent state. Together these data suggest that overexpression of KDM4 proteins induces numerous oncogenic effects.

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CRRD Object Information
CRRD ID: 9588525
Created: 2014-10-29
Species: All species
Last Modified: 2014-10-29
Status: ACTIVE



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