The multitalented Mediator complex.

Authors: Carlsten, JO  Zhu, X  Gustafsson, CM 
Citation: Carlsten JO, etal., Trends Biochem Sci. 2013 Nov;38(11):531-7. doi: 10.1016/j.tibs.2013.08.007. Epub 2013 Sep 25.
Pubmed: (View Article at PubMed) PMID:24074826
DOI: Full-text: DOI:10.1016/j.tibs.2013.08.007

The Mediator complex is needed for regulated transcription of RNA polymerase II (Pol II)-dependent genes. Initially, Mediator was only seen as a protein bridge that conveyed regulatory information from enhancers to the promoter. Later studies have added many other functions to the Mediator repertoire. Indeed, recent findings show that Mediator influences nearly all stages of transcription and coordinates these events with concomitant changes in chromatin organization. We review the multitude of activities associated with Mediator and discuss how this complex coordinates transcription with other cellular events. We also discuss the inherent difficulties associated with in vivo characterization of a coactivator complex that can indirectly affect diverse cellular processes via changes in gene transcription.


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CRRD Object Information
CRRD ID: 9684936
Created: 2014-12-10
Species: All species
Last Modified: 2014-12-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.