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Requirement of TORC1 for late-phase long-term potentiation in the hippocampus.

Authors: Zhou, Y  Wu, H  Li, S  Chen, Q  Cheng, XW  Zheng, J  Takemori, H  Xiong, ZQ 
Citation: Zhou Y, etal., PLoS One. 2006 Dec 20;1:e16.
Pubmed: (View Article at PubMed) PMID:17183642
DOI: Full-text: DOI:10.1371/journal.pone.0000016

Late-phase long-term potentiation (L-LTP) and long-term memory depend on the transcription of mRNA of CRE-driven genes and synthesis of proteins. However, how synaptic signals propagate to the nucleus is unclear. Here we report that the CREB coactivator TORC1 (transducer of regulated CREB activity 1) undergoes neuronal activity-induced translocation from the cytoplasm to the nucleus, a process required for CRE-dependent gene expression and L-LTP. Overexpressing a dominant-negative form of TORC1 or down-regulating TORC1 expression prevented activity-dependent transcription of CREB target genes in cultured hippocampal neurons, while overexpressing a wild-type form of TORC1 facilitated basal and activity-induced transcription of CREB target genes. Furthermore, overexpressing the dominant-negative form of TORC1 suppressed the maintenance of L-LTP without affecting early-phase LTP, while overexpressing the wild-type form of TORC1 facilitated the induction of L-LTP in hippocampal slices. Our results indicate that TORC1 is essential for CRE-driven gene expression and maintenance of long-term synaptic potentiation.

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CRRD Object Information
CRRD ID: 9685167
Created: 2014-12-19
Species: All species
Last Modified: 2014-12-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.