Genetic variation in myelin oligodendrocyte glycoprotein expression and susceptibility to experimental autoimmune encephalomyelitis.

Authors: Pagany, M  Jagodic, M  Bourquin, C  Olsson, T  Linington, C 
Citation: Pagany M, etal., J Neuroimmunol. 2003 Jun;139(1-2):1-8.
Pubmed: (View Article at PubMed) PMID:12799014

Myelin oligodendrocyte glycoprotein (MOG) is encoded within the RT1.M region of the rat MHC a susceptibility locus for MOG-induced experimental autoimmune encephalomyelitis (EAE). We report that the enhanced susceptibility of Brown Norway (BN) rats to MOG-EAE is associated with higher expression of MOG mRNA and protein in the nervous system than in the less susceptible Lewis (LEW) strain. MOG mRNA was also detected in the immune system, but there was no correlation with disease susceptibility. These results suggest that differences in the expression of MOG in the target organ, rather than in the immune system may influence susceptibility to MOG-EAE.


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CRRD Object Information
CRRD ID: 9685373
Created: 2015-01-05
Species: All species
Last Modified: 2015-01-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.