Bone marrow lacking integrin expression facilitates an enhanced susceptibility to EAE in the xenogeneic bone marrow chimeras.

Authors: Robinson, KM  Markwardt, S  Kitzerow, N  Moes, N  Estrada, M  Jones, RE 
Citation: Robinson KM, etal., J Neuroimmunol. 2008 Nov 15;204(1-2):110-7. doi: 10.1016/j.jneuroim.2008.07.001.
Pubmed: (View Article at PubMed) PMID:18722022
DOI: Full-text: DOI:10.1016/j.jneuroim.2008.07.001

Xenotransplantation of rat bone marrow cells (BMC) into immunodeficient (SCID) mice generates chimeric mice susceptible to paralytic autoimmune CNS inflammation. Herein, we identified a disease relevant subset of transplantable BMC lacking expression of CD11b/c and CD49d. Moreover, disease susceptibility was enhanced in the presence of non-myelin specific T-cells. Only the CD11b/c negative population of BM retained the capability to populate the blood, spleen and spinal cord of recipients and matured after transplant to express CD11b/c. These results indicate non-myelin T cells in combination with integrin negative BM represent pre-pathogenic determinants of an enhanced disease susceptibility to myelin reactive T cells.

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CRRD ID: 9698436
Created: 2015-02-16
Species: All species
Last Modified: 2015-02-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.