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Characterization of neurotensin receptors.

Authors: Kitabgi, P  Pelaprat, D 
Citation: Kitabgi P and Pelaprat D, Curr Protoc Pharmacol. 2004 May;Chapter 1:Unit 1.29. doi: 10.1002/0471141755.ph0129s24.
Pubmed: (View Article at PubMed) PMID:22294115
DOI: Full-text: DOI:10.1002/0471141755.ph0129s24

This unit describes procedures for performing competition binding assays with neurotensin receptor subtypes 1 and 2 (NTS1 and NTS2). Binding assays using cloned receptors, brain membranes, and primary cultured mesencephalic neurons are presented. NTS1 binding assays employing either radiolabeled neurotensin or SR 48692 (a nonpeptide neurotensin antagonist) as radioligands are described. These procedures may be used to screen selective ligands at neurotensin receptor subtypes.


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CRRD Object Information
CRRD ID: 9743848
Created: 2015-02-18
Species: All species
Last Modified: 2015-02-18
Status: ACTIVE


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