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Effects of neurotensin in amygdaloid spatial learning mechanisms.

Authors: Laszlo, K  Toth, K  Kertes, E  Peczely, L  Ollmann, T  Lenard, L 
Citation: Laszlo K, etal., Behav Brain Res. 2010 Jul 11;210(2):280-3. doi: 10.1016/j.bbr.2010.02.038. Epub 2010 Feb 26.
Pubmed: (View Article at PubMed) PMID:20219557
DOI: Full-text: DOI:10.1016/j.bbr.2010.02.038

Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms. In Morris water maze test, rats were microinjected with NT or neurotensin receptor-1 (NTS1) antagonist SR 48692 (ANT). NT significantly reduced the escape latency. Effect of NT was blocked by ANT pretreatment. Our results show that in the rat CeA NT facilitates spatial learning. We clarified that NTS1s are involved in this action.


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CRRD Object Information
CRRD ID: 9743918
Created: 2015-02-20
Species: All species
Last Modified: 2015-02-20
Status: ACTIVE


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