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Expression of the nuclear RING finger protein SNURF/RNF4 during rat testis development suggests a role in spermatid maturation.

Authors: Yan, W  Hirvonen-Santti, SJ  Palvimo, JJ  Toppari, J  Janne, OA 
Citation: Yan W, etal., Mech Dev. 2002 Oct;118(1-2):247-53.
Pubmed: (View Article at PubMed) PMID:12351196

A small nuclear RING finger protein, termed SNURF (or RNF4), is a coregulator of androgen receptor-dependent transcription. To elucidate the physiological role of SNURF in vivo, cell type-specific localization and changes in SNURF mRNA and protein accumulation were followed during testicular development and spermatogenesis of the rat. Two SNURF transcripts, approximately 3.0 and 1.6 kb in size, were detected in adult rat testis. Both mRNA species are capable of encoding full-length SNURF protein. The 3.0 kb SNURF mRNA is persistently expressed in Sertoli cells of both immature and mature testes, whereas the expression of the 1.6 kb transcript appears after day 30 of postnatal life and is restricted to step 4-11 spermatids. Increased accumulation of SNURF in step 4-11 spermatids, which do not express the androgen receptor, indicates that SNURF action is not restricted to the regulation of androgen signaling. Germ cell expression of SNURF coincides with the last transcriptional activity of the haploid genome and alterations in chromatin structure, suggesting that SNURF is involved in the regulation of processes required for late steps of spermatid maturation.

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CRRD Object Information
CRRD ID: 9831411
Created: 2015-03-05
Species: All species
Last Modified: 2015-03-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.