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Strain: Ho:ZDFM-Leprfa

Symbol: Ho:ZDFM-Leprfa
Strain: ZDFM-Leprfa
Substrain: Ho
Full Name: Zucker Fatty Diabetes Mellitus rats
Ontology ID: RS:0004404
Alleles: Leprfa;   Lepr
Also known as: Hos:ZFDM-Leprfa; ZFDM rats; Ho:ZDFM-Leprfa
Type: outbred
Source: Hoshino Laboratory Animals, Inc. (Ibaraki, Japan)
Origin: In the Zucker fatty rat colony in Hoshino Laboratory Animals, Inc, they incidentally found fa/fa homozygous male rats having reproductive ability. The Selective breeding using the fa/fa male rats that exhibited relatively high blood glucose levels at 10 weeks of age, resulting in establishment of a diabetic strain. These fa/fa male rats developed diabetes as early as 10 weeks of age, reaching 100% incidence by 21 weeks of age, while none of the fa/+ male rats developed diabetes.
Last Known Status: Unknown

Disease Annotations
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References - curated


Damaging Variants

Additional Information

Nomenclature History
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CRRD Object Information
CRRD ID: 12859279
Created: 2017-04-13
Species: Rattus norvegicus
Last Modified: 2017-04-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.