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Strain: TRM/Kyo

Symbol: TRM/Kyo
Strain: TRM
Substrain: Kyo
Full Name: tremor rat
Ontology ID: RS:0000940
Alleles: Hcn1A354V;   Aspa
Also known as: NBRP Rat No: 0015; MDC-02-29
Type: segregating_inbred
Source: National BioResource Project for the Rat in Japan
Origin: In 1980, a spontaneous tremor mutant rat was found in the colony of Kyo:Wistar (Yamada, 1985). This disorder was found to be caused by an autosomal recessive gene and was designated tremor (tm). Deletion of Aspa gene was identified in the animal with no aspartoacylase activity in the brain and measurable level of activity in the kidney. TRM was established as a segregating inbred strain. In F18 progeny, a rat which did not have tm mutation was separated and established as a control strain of WTC (NBRP No.0020). (Dec 8, 2010)
Coat Color: Albino
Inbred Generations: F51
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-01-03)
Research Usage Neurobiology

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CRRD Object Information
CRRD ID: 1302702
Created: 2004-10-15
Species: Rattus norvegicus
Last Modified: 2005-12-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.