Strain Report - Rat Genome Database

Name: F344/DuCrlCrlj
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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General

Strain: F344/DuCrlCrlj
Symbol:	F344/DuCrlCrlj
Strain:	F344
Substrain:	DuCrlCrlj
Ontology ID:	RS:0000305
Also known as:	F344/DuCrlCrlj; NBRP Rat No: 0506
Type:	inbred
Source:	Charles River Laboratories Japan, National BioResource Project for the Rat in Japan
Origin:	This strain originated in 1920 by Curtis then was with Dunning and then with Charles River Japan from 1976.
Inbred Generations:	F110
Last Known Status:	Live Animals
Research Usage	Neurobiology; Cardio Hypertension

Annotation (Toggle Annotation Detail/Summary View)

Phenotype Annotations

Mammalian Phenotype

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
increased circulating glucose level		QTM		69696		RGD

Phenotype Values via Phenominer

Related Phenotype Data for Term "F344/DuCrlCrlj" (RS:0000305)

Rat Strains:

F344/DuCrlCrlj

Clinical Measurements:

abdominal fat pad weight
activated partial thromboplastin time
blood band neutrophil count to total leukocyte count ratio
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood glucose level
blood glucose level area under curve (AUC)
blood hemoglobin level
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
blood segmented neutrophil count to total leukocyte count ratio
body temperature
body weight
both adrenal glands weight to body weight ratio
both adrenal glands wet weight
both kidneys wet weight
both kidneys wet weight as percentage of body weight
both testes wet weight
both testes wet weight to body weight ratio
brain weight to body weight ratio
brain wet weight
epididymal fat pad weight
heart rate
heart weight to body weight ratio
heart wet weight
hematocrit
liver weight as percentage of body weight
liver wet weight
lung weight to body weight ratio
lung wet weight
mean corpuscular hemoglobin concentration
mean corpuscular hemoglobin level
mean corpuscular volume
mesenteric fat pad weight
non-specified leukocyte count to total leukocyte count ratio
pancreas weight to body weight ratio
pancreas wet weight
percentage of study population developing leukemia during a period of time
percentage of study population developing T-cell lymphomas during a period of time
plasma alanine aminotransferase activity level
plasma albumin level
plasma albumin to plasma total protein ratio
plasma alkaline phosphatase activity level
plasma aspartate aminotransferase activity level
plasma chloride level
plasma creatinine level
plasma free fatty acids level
plasma glucose level
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
plasma phosphate level
plasma potassium level
plasma sodium level
plasma total cholesterol level
plasma total protein level
plasma triglyceride level
plasma urea nitrogen level
platelet count
post-insult time to onset of T-cell lymphoma
prothrombin time
red blood cell count
retroperitoneal fat pad weight
serum high density lipoprotein cholesterol level
serum insulin level
serum leptin level
serum total cholesterol level
serum triglyceride level
spleen weight to body weight ratio
spleen wet weight
systolic blood pressure
timed urine volume
timed urine volume to body weight ratio
total plasma bilirubin level
total plasma calcium level
urine chloride excretion rate to body weight ratio
urine chloride level
urine potassium excretion rate to body weight ratio
urine potassium level
urine sodium excretion rate to body weight ratio
urine sodium level
white blood cell count

Experimental Conditions:

0.9% sodium chloride solution
controlled N-propyl-N-nitrosourea content drinking water
fasting
glucose solution
glucose solution, 2.8M
naive control condition
partial pancreatectomy
specific pathogen-free conditions

Measurement Methods:

automated blood analysis
automated blood electrolyte analysis
automated cell/particle size/count analysis method
automated coagulometer method
automated differential white blood cell count test
automated plasma albumin analysis
automated plasma analysis
automated plasma creatinine analysis
automated plasma protein analysis
automated plasma total protein analysis
automated urine analysis
blood glucose analysis
body weighing method
digital rectal thermometry
electro-chemical glucometer
enzyme linked immunosorbent assay (ELISA)
ex vivo light microscopy with immunohistochemistry
fluorescence-activated cell sorting method
intraperitoneal glucose tolerance test
metabolic cage urine volume measurement method
oral glucose tolerance test
plasma glucose analysis
post excision weight measurement
serum high-density lipoprotein-cholesterol measurement test
serum total cholesterol measurement test
serum triglyceride analysis
Shimadzu electronic balance post excision weight measurement
tail cuff photoplethysmography
whole body digital scale

Phenotype Annotations

Mammalian Phenotype

increased circulating glucose level (QTM)

Experimental Data Annotations

Rat Strain

F344/DuCrlCrlj (IEA)

Phenotype Values via Phenominer

Options:

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View expanded data table

Clinical Measurement

heart rate

systolic blood pressure

body weight

body temperature

red blood cell count

blood hemoglobin level

white blood cell count

platelet count

hematocrit

mean corpuscular volume

plasma glucose level

plasma aspartate aminotransferase activity level

plasma alanine aminotransferase activity level

plasma alkaline phosphatase activity level

blood glucose level

plasma total protein level

plasma albumin level

plasma phosphate level

plasma chloride level

plasma sodium level

plasma potassium level

heart wet weight

heart weight to body weight ratio

both kidneys wet weight

abdominal fat pad weight

lung wet weight

urine potassium level

urine sodium level

brain weight to body weight ratio

both kidneys wet weight as percentage of body weight

liver weight as percentage of body weight

spleen weight to body weight ratio

brain wet weight

lung weight to body weight ratio

liver wet weight

both adrenal glands wet weight

spleen wet weight

both testes wet weight

activated partial thromboplastin time

prothrombin time

timed urine volume

mean corpuscular hemoglobin level

mean corpuscular hemoglobin concentration

blood glucose level area under curve (AUC)

mesenteric fat pad weight

retroperitoneal fat pad weight

epididymal fat pad weight

serum insulin level

serum triglyceride level

serum high density lipoprotein cholesterol level

serum total cholesterol level

blood basophil count to total leukocyte count ratio

blood eosinophil count to total leukocyte count ratio

blood lymphocyte count to total leukocyte count ratio

blood monocyte count to total leukocyte count ratio

total plasma calcium level

urine chloride level

plasma creatinine level

plasma free fatty acids level

plasma triglyceride level

plasma total cholesterol level

plasma urea nitrogen level

both adrenal glands weight to body weight ratio

pancreas wet weight

pancreas weight to body weight ratio

plasma high density lipoprotein cholesterol level

plasma low density lipoprotein cholesterol level

serum leptin level

both testes wet weight to body weight ratio

percentage of study population developing leukemia during a period of time

urine sodium excretion rate to body weight ratio

post-insult time to onset of T-cell lymphoma

percentage of study population developing T-cell lymphomas during a period of time

timed urine volume to body weight ratio

urine chloride excretion rate to body weight ratio

urine potassium excretion rate to body weight ratio

total plasma bilirubin level

blood segmented neutrophil count to total leukocyte count ratio

blood band neutrophil count to total leukocyte count ratio

non-specified leukocyte count to total leukocyte count ratio

plasma albumin to plasma total protein ratio

References - curated

1.	Kose H, etal., Mamm Genome 2002 Oct;13(10):558-62.
2.	Moralejo DH, etal., Proc Assoc Am Physicians 1998 Nov-Dec;110(6):545-58.
3.	Personal communication with Charles River Laboratories
4.	Personal Communication with NBRP
5.	RGD Automated Pipelines
6.	Sugiura K, etal., Mamm Genome 1999 Dec;10(12):1126-31.

Region

Strain QTL Data

Symbol	Name	Trait
Bw21	Body weight QTL 21	body mass (VT:0001259)
Niddm20	Non-insulin dependent diabetes mellitus QTL 20	blood glucose amount (VT:0000188)
Niddm21	Non-insulin dependent diabetes mellitus QTL 21	blood glucose amount (VT:0000188)
Niddm22	Non-insulin dependent diabetes mellitus QTL 22	blood glucose amount (VT:0000188)
Niddm23	Non-insulin dependent diabetes mellitus QTL 23	blood glucose amount (VT:0000188)
Niddm24	Non-insulin dependent diabetes mellitus QTL 24	blood glucose amount (VT:0000188)
Niddm25	Non-insulin dependent diabetes mellitus QTL 25	blood glucose amount (VT:0000188)
Niddm26	Non-insulin dependent diabetes mellitus QTL 26	blood glucose amount (VT:0000188)
Niddm27	Non-insulin dependent diabetes mellitus QTL 27	blood glucose amount (VT:0000188)
Niddm28	Non-insulin dependent diabetes mellitus QTL 28	blood glucose amount (VT:0000188)
Niddm29	Non-insulin dependent diabetes mellitus QTL 29	blood glucose amount (VT:0000188)
Niddm30	Non-insulin dependent diabetes mellitus QTL 30	blood glucose amount (VT:0000188)
Niddm31	Non-insulin dependent diabetes mellitus QTL 31	blood glucose amount (VT:0000188)
Niddm32	Non-insulin dependent diabetes mellitus QTL 32	blood glucose amount (VT:0000188)
Niddm52	Non-insulin dependent diabetes mellitus QTL 52	blood glucose amount (VT:0000188)
Niddm53	Non-insulin dependent diabetes mellitus QTL 53	blood glucose amount (VT:0000188)
Niddm54	Non-insulin dependent diabetes mellitus QTL 54	blood glucose amount (VT:0000188)
Niddm55	Non-insulin dependent diabetes mellitus QTL 55	blood glucose amount (VT:0000188)
Niddm56	Non-insulin dependent diabetes mellitus QTL 56	blood glucose amount (VT:0000188)
Pancm5	Pancreatic morphology QTL 5	pancreas mass (VT:0010144)

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
F344/DuCrlCrlj (KyushuU)		1222

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_drgs_chems	Neural tumors were seen after 60mg/kg ENU was given to pregnant rats.	2316901

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-05-29	F344/DuCrlCrlj		F344/DuCrlCrlj		Name updated	68913	APPROVED
2012-05-29	F344/DuCrlCrlj		F344/DuCrlCrlj		Name updated	68913	APPROVED

More on this Strain
	Strain Nomenclature
	Strain Registration

CRRD Object Information
CRRD ID:	69643
Created:	2001-12-05
Species:	Rattus norvegicus
Last Modified:	2009-06-18
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Strain: F344/DuCrlCrlj

Related Phenotype Data for Term "F344/DuCrlCrlj" (RS:0000305)