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Strain: WKY/N

Symbol: WKY/N
Strain: WKY
Substrain: N
Ontology ID: RS:0000714
Also known as: RRRC:00190
Type: inbred
Source: NIH Autoimmune Rat Model Repository and Development Center, Rat Resource and Research Center
Origin: National Institutes of Health in 1971 from outbred Wistar stock from Kyoto School of Medicine. Inbred as a normotensive control strain for SHR (Hanesn et al 1973), though there is some controversy about the validity of such use (see Rapp 1987). Johnson et al (1992) found large genetic differences using restriction fragment length polymorphisms between WKY and SHR, comparable to the maximum divergence possible between unrelated humans. Also, breeding stock of ths strain was distributed before F20, possibly resulting in the emergence of a number of strains or substrains (Kurtz and Morris 1987, Kurtz et al 1989). It is therefore essential that subline codes are always used in designating this strain.
Genetic Markers: a, B, c, h, P, R
Coat Color: Albino
Inbred Generations: F46 (N)
Last Known Status: Cryopreserved Embryo (as of 2019-02-01)

References - curated


Strain QTL Data
Damaging Variants

Additional Information

RGD Curation Notes
Nomenclature History
More on this Strain
Strain Nomenclature
Strain Registration

CRRD Object Information
CRRD ID: 70454
Created: 2002-04-17
Species: Rattus norvegicus
Last Modified: 2003-11-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.