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The Hybrid Rat Diversity Panel

The Hybrid Rat Diversity Panel
The Hybrid Rat Diversity Panel (HRDP) is a panel of 96 inbred rat strains carefully chosen to maximize power to detect specific genetic loci associated with a complex trait and to maximize the genetic diversity among strains. The HRDP includes 33 genetically diverse inbred strains of rat and two panels of recombinant inbred rat strains, the FXLE/LEXF (33 strains) from Japan and the HXB/BXH (30 strains) from the Czech Republic. Recombinant inbred strains are panels of inbred strains derived from two inbred parental rat strains. The two parental strains are crossed to produce F1 pups. F1 pups are subsequently intercrossed to create an F2 generation. These genetically unique F2 generation rats are paired as founders and brother-sister mated for at least 20 generations to fix their genomes. The two RI panels used in the HRDP have been well characterized through studies focused on seizures, epilepsy, lymphoma and leukemia, blood pressure regulation, metabolic syndrome, and alcohol consumption.

The HXB/BXH recombinant inbred strains were derived from the Spontaneously Hypertensive Rat (SHR/Olalpcv) and the normotensive BN-Lx (BN-Lx/Cub), a Brown Norway congenic rat strain with polydactyly-luxate syndrome. The FXLE x LEXF recombinant inbred strains were derived from the Long Evans strain (LE/Stm) and the Fischer F344 strain (F344/Stm).

The strains included in the HRDP panel are:

 

Strain RGD ID Strain RGD ID Strain RGD ID
ACI/EurMcwi 7364991 HTX/Kyo 1302600 PD/Cub 728161
BDIX/NemOda 2304285 LE/Stm 629485 PVG/Seac 1302722
BN/NHsdMcwi 61498 LEW/Crl 737932 RCS/LavRrrc 1358258
BN-Lx/Cub 61117 LH/MavRrrc 60990 SBH/Ygl 631572
BUF/Mna 61118 LL/MavRrrc 68077 SBN/Ygl 631573
COP/CrCrl 1358153 LN/MavRrrc 61015 SHR/OlaIpcv 631848
DA/OlaHsd 734475 LOU/MNCr 9999143 SHRSP/A3NCrl 2311051
F344/NCrl 737926 M520/N 10024 SR/JrHsd 1582184
F344/Stm 1302686 MNS/N 2307319 SS/JrHsdMcwi 61499
FHH/EurMcwi 629509 MR/N 70449 WAG/RijCrl 2312498
GK/FarMcwi 10395297 MWF/Hsd 737906 WKY/NCrl 1358112

 

 

SHR and BN-Lx derived RI strains Long Evans and F344 derived RI strains
Strain RGD ID Strain RGD ID
HXB/lpcv RI panel 61099 FXLE/Stm RI panel 7244374
BXH/lpcv RI panel 61098 LEXF/Stm RI panel 629500

 


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.